{"id":5420,"date":"2025-10-09T10:46:12","date_gmt":"2025-10-09T10:46:12","guid":{"rendered":"https:\/\/medical.biomarin.com\/en-us\/?page_id=5420"},"modified":"2026-02-17T15:38:01","modified_gmt":"2026-02-17T15:38:01","slug":"hypochondroplasia-clinical-program","status":"publish","type":"page","link":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/","title":{"rendered":"Hypochondroplasia Clinical Program"},"content":{"rendered":"<div id=\"acf-block-68710d6459d61\" class=\"hero hero-no-overlay hero-large-first-para\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/medical.biomarin.com\/en-us\/wp-content\/uploads\/sites\/2\/2025\/10\/Program-banner-bones.png?v=1.20);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/medical.biomarin.com\/en-us\/wp-content\/uploads\/sites\/2\/2025\/10\/Program-banner-bones-Mobile.png?v=1.20);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t        <ul class=\"breadcrumb\">\n\t\t\t            \t\t\t                                                                        <li><a href=\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/\">Hypochondroplasia<\/a><\/li>\n                            \t\t\t                                                                        <li>Hypochondroplasia Clinical Program<\/li>\n                            \t\t\t            \t\t\t        <\/ul>\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>Clinical Program\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Learn about hypochondroplasia clinical trials and research at BioMarin<\/p>\n\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                    \t\t\t\t        <a class=\"button button-arrow\" href=\"https:\/\/clinicaltrials.biomarin.com\/areas-of-clinical-research\/hypochondroplasia\/\" target=\"_blank\">Visit the BioMarin Clinical Trials website<\/a>\t\t\t\t                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-68cc1503e2b9e\" class=\"vblock pipeline pipeline-listing-wrapper\">\n    <!-- Pipeline Filter Header\n    Integration notes:\n    - Toggle button-filter-active class to filter button when active\n    - Component here is generic filter header and is also used for resources (filters themselves differ)\n    -->\n    <div class=\"block filter-header\">\n        <div class=\"wrapper\">\n            <div class=\"inner-wrapper\">\n                <h1>Hypochondroplasia Pipeline<\/h1>\n                \n                                    <div class=\"filters\">\n                        <a class=\"button button-filter\" href=\"#\"><span>Search\/Filter<\/span><\/a>\n                        <div class=\"filters-content\">\n                            <div class=\"wrapper\">\n                                <div class=\"inner-wrapper\">\n                                    <form>\n                                        <fieldset>\n                                            <legend>Filter by phase:<\/legend>\n                                            <div class=\"filter-checkboxes\">\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-pre-ind\">\n                                                    <label for=\"filter-phase-pre-ind\">Pre-IND<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-observational\">\n                                                    <label for=\"filter-phase-observational\">Observational<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-1\">\n                                                    <label for=\"filter-phase-1\">Phase 1<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-2\">\n                                                    <label for=\"filter-phase-2\">Phase 2<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-3\">\n                                                    <label for=\"filter-phase-3\">Phase 3<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-4\">\n                                                    <label for=\"filter-phase-4\">Phase 4<\/label>\n                                                <\/div>\n                                            <\/div>\n                                        <\/fieldset>\n    \n                                                                                \n                                            \n                                                                                    <fieldset>\n                                                <legend>Filter by status:<\/legend>\n                                                <div class=\"filter-checkboxes\">\n                                                                                                                                                                                                                                                                                        <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-active-not-recruiting\" value=\"filter-rec-stat-active-not-recruiting\">\n                                                                <label for=\"filter-rec-stat-active-not-recruiting\">Active, Not Recruiting<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-recruiting\" value=\"filter-rec-stat-recruiting\">\n                                                                <label for=\"filter-rec-stat-recruiting\">Recruiting<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-enrolling-by-invitation\" value=\"filter-rec-stat-enrolling-by-invitation\">\n                                                                <label for=\"filter-rec-stat-enrolling-by-invitation\">Enrolling by Invitation<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-not-started\" value=\"filter-rec-stat-not-started\">\n                                                                <label for=\"filter-rec-stat-not-started\">Not started<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-not-yet-recruiting\" value=\"filter-rec-stat-not-yet-recruiting\">\n                                                                <label for=\"filter-rec-stat-not-yet-recruiting\">Not yet recruiting<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-terminated\" value=\"filter-rec-stat-terminated\">\n                                                                <label for=\"filter-rec-stat-terminated\">Terminated<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-completed\" value=\"filter-rec-stat-completed\">\n                                                                <label for=\"filter-rec-stat-completed\">Completed<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-withdrawn\" value=\"filter-rec-stat-withdrawn\">\n                                                                <label for=\"filter-rec-stat-withdrawn\">Withdrawn<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-unknown-status\" value=\"filter-rec-stat-unknown-status\">\n                                                                <label for=\"filter-rec-stat-unknown-status\">Unknown status<\/label>\n                                                            <\/div>\n                                                                                                                                                            <\/div>\n                                            <\/fieldset>\n                                            \n                                        <div class=\"filter-footer\">\n                                            <div class=\"filter-footer-reset\">\n                                                <a class=\"button button-text\" href=\"#\">Reset all filters<\/a>\n                                            <\/div>\n                                            <div class=\"filter-footer-submit\">\n                                                <a class=\"button button-text\" href=\"#\">Cancel<\/a>\n                                                <input type=\"submit\" class=\"button\" value=\"Apply filters\">\n                                            <\/div>\n                                        <\/div>\n                                    <\/form>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n\n    <!-- Research Pipeline block -->\n    <div class=\"block bg-band pipeline-listing-main\">\n        <div class=\"wrapper\">\n            <div class=\"inner-wrapper\">\n                                                                            \n                                        <div class=\"pipeline-listing pipeline-skeletal-conditions\">\n                        <h2 class=\"h3\">Skeletal Conditions<\/h2>\n\n                                                                                                                                        <h3 class=\"h5 trial-phase trial-phase\">Trial phase<\/h3>\n\n                            <div class=\"pipeline-group\" data-trial-phase-class=\"trial-phase\">\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \n                                                                            <div class=\"pipeline-headers\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">Product (Trial)<\/div>\n                                                <div class=\"pipeline-condition\">Condition<\/div>\n                                                <div class=\"pipeline-technology\">Technology<\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                        <\/div>\n                                    \n                                    \n                                    <article class=\"pipeline-trial pre-ind phase-1 phase-2 filter-condition-hypochondroplasia filter-tech-peptide filter-rec-stat-recruiting\">\n                                        <div class=\"pipeline-summary\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">\n                                                    <h3 class=\"h5\">Vosoritide<\/h3>\n                                                    <p>(111-212 [Canopy HCH-2I])<\/p>\n                                                    <p class=\"status\"><span class=\"label\">Trial Status<\/span> <span class=\"status\">Recruiting<\/span><\/p>\n                                                <\/div>\n                                                                                                    <div class=\"pipeline-condition\">\n                                                        <h4 class=\"h5\">Condition<\/h4>\n                                                        <p>Hypochondroplasia<\/p>\n                                                    <\/div>\n                                                                                                                                                    <div class=\"pipeline-technology\">\n                                                        <h4 class=\"h5\">Technology<\/h4>\n                                                        <ul>\n                                                            <li>Peptide<\/li>\n                                                        <\/ul>\n                                                    <\/div>\n                                                                                                <div class=\"pipeline-details\">\n                                                                                                            <h4>Title<\/h4>\n                                                        <p>A Study of Vosoritide Versus Placebo in Children With Hypochondroplasia Aged 0 to &lt; 36 Months<\/p>\n                                                    \n                                                                                                            <h4>Study Description<\/h4>\n                                                        <p>The purpose of this study is to evaluate the safety and efficacy of daily administration of vosoritide in participants with Hypochondroplasia aged 0 to &lt; 36 months over a 52-week period.<\/p>\n                                                    \n                                                                                                            <div class=\"detail-boxes\">\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Primary Outcome Measures*<\/h4>\n<ul>\n<li>Incidence of treatment-emergent adverse events and serious adverse events<\/li>\n<li>Change from baseline in standard clinical laboratory values (hematology, urinalysis, and chemistry), heart rate, respiratory rate, temperature, blood pressure, and height Z-score<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Inclusion Criteria*<\/h4>\n<ul>\n<li>0 to &lt; 36 months of age<\/li>\n<li>Weight at Day 1 visit (pre-treatment) &#x2265;3 kg<\/li>\n<li>Have a confirmed genetic diagnosis of HCH (obtained via whole genome sequencing; presence of a FGFR3 pathogenic variant associated with HCH)<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Secondary Outcome Measures*<\/h4>\n<ul>\n<li>Change in height<\/li>\n<li>Cumulative annualized growth velocity (AGV)<\/li>\n<li>6-month interval AGV<\/li>\n<li>Change from baseline in upper to lower body segment ratio<\/li>\n<li>Change from baseline in arm span<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Exclusion Criteria*<\/h4>\n<ul>\n<li>Short stature condition other than HCH<\/li>\n<li>Have an unstable medical condition likely to require surgical intervention during the study period<\/li>\n<li>Have been treated with growth hormone, insulin-like growth factor 1 (IGF-1), or anabolic steroids in the 6 months prior to Screening, or long-term treatment (&gt; 3 months) at any time<\/li>\n<li>Have used any other investigational product or investigational medical device for the treatment of HCH or short stature at any time<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                    <\/div>\n                                                    \n                                                    <p>* Additional measures\/criteria may apply.<br>\nHCH, Hypochondroplasia;<\/p>\n                                                                                                            <p><a class=\"button button-text button-external\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT07126262\" target=\"_blank\">For reference and comprehensive trial information, visit ClinicalTrials.gov NCT07126262<\/a><\/p>\n                                                                                                    <\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases pipeline-inline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-expand\">\n                                                    <div class=\"trigger\"><\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/article>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \n                                    \n                                    \n                                    <article class=\"pipeline-trial pre-ind phase-1 phase-2 phase-3 filter-condition-hypochondroplasia filter-tech-peptide filter-rec-stat-active-not-recruiting\">\n                                        <div class=\"pipeline-summary\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">\n                                                    <h3 class=\"h5\">Vosoritide<\/h3>\n                                                    <p>(111-303 [Canopy HCH-3])<\/p>\n                                                    <p class=\"status\"><span class=\"label\">Trial Status<\/span> <span class=\"status\">Active, Not Recruiting<\/span><\/p>\n                                                <\/div>\n                                                                                                    <div class=\"pipeline-condition\">\n                                                        <h4 class=\"h5\">Condition<\/h4>\n                                                        <p>Hypochondroplasia<\/p>\n                                                    <\/div>\n                                                                                                                                                    <div class=\"pipeline-technology\">\n                                                        <h4 class=\"h5\">Technology<\/h4>\n                                                        <ul>\n                                                            <li>Peptide<\/li>\n                                                        <\/ul>\n                                                    <\/div>\n                                                                                                <div class=\"pipeline-details\">\n                                                                                                            <h4>Title<\/h4>\n                                                        <p>Interventional Study of Vosoritide for the Treatment of Children With Hypochondroplasia<\/p>\n                                                    \n                                                                                                            <h4>Study Description<\/h4>\n                                                        <p>The intent and design of this Phase 3 study is to assess vosoritide as a therapeutic option for the treatment of children with hypochondroplasia (HCH).<\/p>\n                                                    \n                                                                                                            <div class=\"detail-boxes\">\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Primary Outcome Measure*<\/h4>\n<ul>\n<li>Change from baseline in annualized growth velocity (AGV)<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Inclusion Criteria*<\/h4>\n<ul>\n<li>Patients &ge; 3 to &lt; 18 years of age<\/li>\n<li>Confirmed genetic diagnosis of HCH<\/li>\n<li>A height Z score of &#x2264;-2 standard deviations in reference to the general population of the same age and sex, as calculated using the Center for Disease Control and Prevention (CDC) growth charts<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Secondary Outcome Measure*<\/h4>\n<ul>\n<li>Change from baseline in standing height and height Z-score<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Exclusion Criteria*<\/h4>\n<ul>\n<li>Have an unstable condition likely to require surgical intervention during the study<\/li>\n<li>Evidence of decreased growth velocity and\/or growth plate closure<\/li>\n<li>Treated with growth hormone, insulin-like growth factor 1 (IGF-1), or anabolic steroids<\/li>\n<li>Planned or expected to have limb-lengthening surgery or bone-related surgery (ie, surgery involving disruption of bone cortex, excluding tooth extraction) during the study period<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                    <\/div>\n                                                    \n                                                    <p>* Additional measures\/criteria may apply.<br>\nHCH, hypochondroplasia.<\/p>\n                                                                                                            <p><a class=\"button button-text button-external\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06455059\" target=\"_blank\">For reference and comprehensive trial information, visit ClinicalTrials.gov NCT06455059<\/a><\/p>\n                                                                                                    <\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases pipeline-inline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-expand\">\n                                                    <div class=\"trigger\"><\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/article>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \n                                    \n                                    \n                                    <article class=\"pipeline-trial pre-ind phase-1 phase-2 phase-3 filter-condition-hypochondroplasia filter-tech-peptide filter-rec-stat-enrolling-by-invitation\">\n                                        <div class=\"pipeline-summary\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">\n                                                    <h3 class=\"h5\">Vosoritide<\/h3>\n                                                    <p>(111-308 [Canopy HCH-3 EXT])<\/p>\n                                                    <p class=\"status\"><span class=\"label\">Trial Status<\/span> <span class=\"status\">Enrolling by Invitation<\/span><\/p>\n                                                <\/div>\n                                                                                                    <div class=\"pipeline-condition\">\n                                                        <h4 class=\"h5\">Condition<\/h4>\n                                                        <p>Hypochondroplasia<\/p>\n                                                    <\/div>\n                                                                                                                                                    <div class=\"pipeline-technology\">\n                                                        <h4 class=\"h5\">Technology<\/h4>\n                                                        <ul>\n                                                            <li>Peptide<\/li>\n                                                        <\/ul>\n                                                    <\/div>\n                                                                                                <div class=\"pipeline-details\">\n                                                                                                            <h4>Title<\/h4>\n                                                        <p>Long-Term Extension Study of Vosoritide to Treat Children With Hypochondroplasia (CANOPY-HCH-EXT)<\/p>\n                                                    \n                                                                                                            <h4>Study Description<\/h4>\n                                                        <p>The purpose of this study is to evaluate the long-term safety and efficacy of daily doses of vosoritide in participants with HCH<\/p>\n                                                    \n                                                                                                            <div class=\"detail-boxes\">\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Primary Outcome Measure*<\/h4>\n<ul>\n<li>Change from baseline in height Z-score<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Inclusion Criteria*<\/h4>\n<ul>\n<li>Completed the Week 52 visit for Study 111-303 or 111-212 and have open epiphyses as assessed by left hand antero-posterior (AP) X-rays<\/li>\n<li>Females &#x2265; 10 years old or who have begun menses must have a negative pregnancy test at the Baseline visit and be willing to have additional pregnancy tests during the study<\/li>\n<li>If sexually active, participants must be willing to use a highly effective method of contraception while participating in the study<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Secondary Outcome Measures*<\/h4>\n<ul>\n<li>Change from baseline in height<\/li>\n<li>Absolute 6- or 12-month interval AGV<\/li>\n<li>Change from baseline in upper to lower body segment ratio<\/li>\n<li>Change from baseline in Quality of Life In Short-Statured Youth (QoLISSY) total score<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Exclusion Criteria*<\/h4>\n<ul>\n<li>Permanently discontinued study treatment in Study 111-303 or 111-212<\/li>\n<li>Evidence of decreased growth velocity (AGV &lt;1.5 cm\/year) as assessed over a period of at least 6 months and growth plate closure assessed as per standard of care<\/li>\n<li>Planned or expected to have limb-lengthening surgery during the study period<\/li>\n<li>Planned or expected bone-related surgery during the study period<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                    <\/div>\n                                                    \n                                                    <p>* Additional measures\/criteria may apply.<\/p>\n                                                                                                            <p><a class=\"button button-text button-external\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT07073014?lead=BioMarin%20Pharmaceutical&amp;aggFilters=status:enr%20act%20rec%20unk&amp;rank=1\" target=\"_blank\">For reference and comprehensive trial information, visit ClinicalTrials.gov NCT07073014<\/a><\/p>\n                                                                                                    <\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases pipeline-inline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-expand\">\n                                                    <div class=\"trigger\"><\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/article>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \n                                    \n                                    \n                                    <article class=\"pipeline-trial observational filter-condition-hypochondroplasia filter-tech-observational filter-rec-stat-not-started\">\n                                        <div class=\"pipeline-summary\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">\n                                                    <h3 class=\"h5\">Hypochondroplasia<\/h3>\n                                                    <p>(111-809)<\/p>\n                                                    <p class=\"status\"><span class=\"label\">Trial Status<\/span> <span class=\"status\">Not started<\/span><\/p>\n                                                <\/div>\n                                                                                                    <div class=\"pipeline-condition\">\n                                                        <h4 class=\"h5\">Condition<\/h4>\n                                                        <p>Hypochondroplasia<\/p>\n                                                    <\/div>\n                                                                                                                                                    <div class=\"pipeline-technology\">\n                                                        <h4 class=\"h5\">Technology<\/h4>\n                                                        <ul>\n                                                            <li>Observational<\/li>\n                                                        <\/ul>\n                                                    <\/div>\n                                                                                                <div class=\"pipeline-details\">\n                                                                                                            <h4>Title<\/h4>\n                                                        <p>Generating Growth Curves for Standing and Sitting Height in Hypochondroplasia: A Multi-Center Retrospective Natural History Study<\/p>\n                                                    \n                                                                                                            <h4>Study Description<\/h4>\n                                                        <p>This study will be a retrospective chart review of height measurements in patients &#x2264;18 years old with a clinically or genetically confirmed diagnosis of hypochondroplasia (HCH)<\/p>\n                                                    \n                                                                                                            <div class=\"detail-boxes\">\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Primary Outcome Measure*<\/h4>\n<ul>\n<li>To develop sex- and age-specific growth curves for height (standing and sitting, as well as lower-to-upper body segment) for patients with HCH<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Secondary Outcome Measure*<\/h4>\n<ul>\n<li>To calculate sex- and age-specific Z-scores (referenced to Centers for Disease Control and Prevention [CDC] average stature) for height (standing and sitting) in patients with HCH<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                    <\/div>\n                                                    \n                                                    <p>* Additional measures\/criteria may apply.<sup>12<\/sup><\/p>\n                                                                                                    <\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases pipeline-inline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-expand\">\n                                                    <div class=\"trigger\"><\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/article>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \n                                    \n                                    \n                                    <article class=\"pipeline-trial observational filter-condition-hypochondroplasia filter-tech-observational filter-rec-stat-recruiting\">\n                                        <div class=\"pipeline-summary\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">\n                                                    <h3 class=\"h5\">Hypochondroplasia<\/h3>\n                                                    <p>(111-902 [Canopy HCH-OS])<\/p>\n                                                    <p class=\"status\"><span class=\"label\">Trial Status<\/span> <span class=\"status\">Recruiting<\/span><\/p>\n                                                <\/div>\n                                                                                                    <div class=\"pipeline-condition\">\n                                                        <h4 class=\"h5\">Condition<\/h4>\n                                                        <p>Hypochondroplasia<\/p>\n                                                    <\/div>\n                                                                                                                                                    <div class=\"pipeline-technology\">\n                                                        <h4 class=\"h5\">Technology<\/h4>\n                                                        <ul>\n                                                            <li>Observational<\/li>\n                                                        <\/ul>\n                                                    <\/div>\n                                                                                                <div class=\"pipeline-details\">\n                                                                                                            <h4>Title<\/h4>\n                                                        <p>A Multicenter Multinational Observational Study of Children With Hypochondroplasia<\/p>\n                                                    \n                                                                                                            <h4>Study Description<\/h4>\n                                                        <p>This study will collect growth measurements and other variables of interest to assess growth and the clinical course of hypochondroplasia over time.<\/p>\n                                                    \n                                                                                                            <div class=\"detail-boxes\">\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Primary Outcome Measures*<\/h4>\n<ul>\n<li>\nChange in growth (annualized growth velocity, height Z-score, height)\n<\/li>\n<li>\nChange in anthropometric measures (body mass index [BMI], upper and lower length ratio, arms spam to standing height ratio)\n<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Inclusion Criteria*<\/h4>\n<ul>\n<li>\nPatients &#x2264; 15 years of age\n<\/li>\n<li>\nGenetic confirmation of hypochondroplasia\n<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Secondary Outcome Measures*<\/h4>\n<ul>\n<li>\nChange in quality of life and patient and caregiver assessments of disease severity\n<\/li>\n<li>\nRates of medical events of interest\n<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Exclusion Criteria*<\/h4>\n<ul>\n<li>\nDiagnosis of genetic short stature condition other than hypochondroplasia or a genetic variant known to cause another genetic syndrome associated with short stature\n<\/li>\n<li>\nReceived an investigational product or medical device within the last 6 months\n<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                    <\/div>\n                                                    \n                                                    <p>* Additional measures\/criteria may apply.<\/p>\n                                                                                                            <p><a class=\"button button-text button-external\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT06212947\" target=\"_blank\">For reference and comprehensive trial information, visit ClinicalTrials.gov NCT06212947<\/a><\/p>\n                                                                                                    <\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases pipeline-inline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-expand\">\n                                                    <div class=\"trigger\"><\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/article>\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \n                                    \n                                    \n                                    <article class=\"pipeline-trial pre-ind phase-1 filter-condition-achondroplasia-hypochondroplasia filter-tech-peptide filter-rec-stat-not-started\">\n                                        <div class=\"pipeline-summary\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">\n                                                    <h3 class=\"h5\">BMN 333<\/h3>\n                                                    <p>Long-acting CNP<\/p>\n                                                    <p class=\"status\"><span class=\"label\">Trial Status<\/span> <span class=\"status\">Not started<\/span><\/p>\n                                                <\/div>\n                                                                                                    <div class=\"pipeline-condition\">\n                                                        <h4 class=\"h5\">Condition<\/h4>\n                                                        <p>Achondroplasia, Hypochondroplasia<\/p>\n                                                    <\/div>\n                                                                                                                                                    <div class=\"pipeline-technology\">\n                                                        <h4 class=\"h5\">Technology<\/h4>\n                                                        <ul>\n                                                            <li>Peptide<\/li>\n                                                        <\/ul>\n                                                    <\/div>\n                                                                                                <div class=\"pipeline-details\">\n                                                    \n                                                    \n                                                    \n                                                                                                                                                        <\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases pipeline-inline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-expand\">\n                                                    <div class=\"trigger\"><\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/article>\n                                                            <\/div>\n                                            <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":2,"featured_media":0,"parent":4705,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-5420","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.1.1 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Hypochondroplasia Clinical Program | BioMarin Medical<\/title>\n<meta name=\"description\" content=\"Learn about hypochondroplasia clinical trials and research at BioMarin\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hypochondroplasia Clinical Program | BioMarin Medical\" \/>\n<meta property=\"og:description\" content=\"Learn about hypochondroplasia clinical trials and research at BioMarin\" \/>\n<meta property=\"og:url\" content=\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/\" \/>\n<meta property=\"og:site_name\" content=\"BioMarin Medical\" \/>\n<meta property=\"article:modified_time\" content=\"2026-02-17T15:38:01+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/\",\"url\":\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/\",\"name\":\"Hypochondroplasia Clinical Program | BioMarin Medical\",\"isPartOf\":{\"@id\":\"https:\/\/medical.biomarin.com\/en-us\/#website\"},\"datePublished\":\"2025-10-09T10:46:12+00:00\",\"dateModified\":\"2026-02-17T15:38:01+00:00\",\"description\":\"Learn about hypochondroplasia clinical trials and research at BioMarin\",\"breadcrumb\":{\"@id\":\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/medical.biomarin.com\/en-us\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Hypochondroplasia\",\"item\":\"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Hypochondroplasia Clinical Program\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/medical.biomarin.com\/en-us\/#website\",\"url\":\"https:\/\/medical.biomarin.com\/en-us\/\",\"name\":\"BioMarin Medical\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/medical.biomarin.com\/en-us\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Hypochondroplasia Clinical Program | BioMarin Medical","description":"Learn about hypochondroplasia clinical trials and research at BioMarin","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/","og_locale":"en_US","og_type":"article","og_title":"Hypochondroplasia Clinical Program | BioMarin Medical","og_description":"Learn about hypochondroplasia clinical trials and research at BioMarin","og_url":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/","og_site_name":"BioMarin Medical","article_modified_time":"2026-02-17T15:38:01+00:00","twitter_card":"summary_large_image","schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/","url":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/","name":"Hypochondroplasia Clinical Program | BioMarin Medical","isPartOf":{"@id":"https:\/\/medical.biomarin.com\/en-us\/#website"},"datePublished":"2025-10-09T10:46:12+00:00","dateModified":"2026-02-17T15:38:01+00:00","description":"Learn about hypochondroplasia clinical trials and research at BioMarin","breadcrumb":{"@id":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/hypochondroplasia-clinical-program\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/medical.biomarin.com\/en-us\/"},{"@type":"ListItem","position":2,"name":"Hypochondroplasia","item":"https:\/\/medical.biomarin.com\/en-us\/hypochondroplasia\/"},{"@type":"ListItem","position":3,"name":"Hypochondroplasia Clinical Program"}]},{"@type":"WebSite","@id":"https:\/\/medical.biomarin.com\/en-us\/#website","url":"https:\/\/medical.biomarin.com\/en-us\/","name":"BioMarin Medical","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/medical.biomarin.com\/en-us\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"}]}},"_links":{"self":[{"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/pages\/5420","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/comments?post=5420"}],"version-history":[{"count":14,"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/pages\/5420\/revisions"}],"predecessor-version":[{"id":6486,"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/pages\/5420\/revisions\/6486"}],"up":[{"embeddable":true,"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/pages\/4705"}],"wp:attachment":[{"href":"https:\/\/medical.biomarin.com\/en-us\/wp-json\/wp\/v2\/media?parent=5420"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}