{"id":6899,"date":"2026-06-05T20:26:23","date_gmt":"2026-06-05T20:26:23","guid":{"rendered":"https:\/\/medical.biomarin.com\/en-us\/?page_id=6899"},"modified":"2026-06-08T14:24:56","modified_gmt":"2026-06-08T14:24:56","slug":"bmn-333","status":"publish","type":"page","link":"https:\/\/medical.biomarin.com\/en-us\/bmn-333\/","title":{"rendered":"BMN 333"},"content":{"rendered":"<div id=\"acf-block-68de3cac2ef74\" class=\"hero hero-no-overlay hero-large-first-para\">\n            <div class=\"hero-background-image hero-background-image-desktop\" style=\"background-image: url(https:\/\/medical.biomarin.com\/en-us\/wp-content\/uploads\/sites\/2\/2025\/10\/Program-banner-bones.png?v=1.22);\"><\/div>\n\t    <div class=\"hero-background-image hero-background-image-mobile\" style=\"background-image: url(https:\/\/medical.biomarin.com\/en-us\/wp-content\/uploads\/sites\/2\/2025\/10\/Program-banner-bones-Mobile.png?v=1.22);\"><\/div>\n    \t<div class=\"overlay\"><\/div>\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"hero-content\">\n\t\t\t    \t\t\t\t\t\t\t\t\t\t\t\t    <h1>BMN 333\n<\/h1>\n\t\t\t\t\t\t\t\t\t\t\t\t    <p>Learn more about BioMarin research in Long-Acting CNP<\/p>\n\t\t\t\t\t\t\t\t\n                <p class=\"inline-buttons\">\n                                                        <\/p>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div id=\"acf-block-68e7d6279a7e3\" class=\"block cards cards-2-col\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\t\t\t<div class=\"cards-title\">\n\t\t\t    \t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"cards-wrapper\">\n\t\t\t    \n<div id=\"acf-block-68e7d6279ad98\" class=\"card card-product card-fixed-button\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                            <h4>Clinical Program\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-arrow\" href=\"#acf-block-68e7d627a167c\" target=\"_self\">See clinical trials<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\n<div id=\"acf-block-68e7d6279ae37\" class=\"card card-product card-fixed-button\" data-muted-autoplay=\"false\">\n        <div class=\"card-content\">\n                            <h4>Congress Posters and Presentations\n<\/h4>\n        \n                                                                                                                                                                                                                                                                                    \n                                                                                        <\/div>\n                                <div class=\"card-actions\">\n                            \n                            <p><a class=\"button button-arrow\" href=\"#acf-block-68ecfd62c135f\" target=\"_self\">See posters &amp; presentations<\/a><\/p>\n                                                                                    <\/div>\n<\/div>\n\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div id=\"acf-block-68e7d627a167c\" class=\"vblock pipeline pipeline-listing-wrapper\">\n    <!-- Pipeline Filter Header\n    Integration notes:\n    - Toggle button-filter-active class to filter button when active\n    - Component here is generic filter header and is also used for resources (filters themselves differ)\n    -->\n    <div class=\"block filter-header\">\n        <div class=\"wrapper\">\n            <div class=\"inner-wrapper\">\n                <h1>BMN 333 Long-Acting CNP Research<\/h1>\n                \n                                    <div class=\"filters\">\n                        <a class=\"button button-filter\" href=\"#\"><span>Search\/Filter<\/span><\/a>\n                        <div class=\"filters-content\">\n                            <div class=\"wrapper\">\n                                <div class=\"inner-wrapper\">\n                                    <form>\n                                        <fieldset>\n                                            <legend>Filter by phase:<\/legend>\n                                            <div class=\"filter-checkboxes\">\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-pre-ind\">\n                                                    <label for=\"filter-phase-pre-ind\">Pre-IND<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-observational\">\n                                                    <label for=\"filter-phase-observational\">Observational<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-1\">\n                                                    <label for=\"filter-phase-1\">Phase 1<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-2\">\n                                                    <label for=\"filter-phase-2\">Phase 2<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-3\">\n                                                    <label for=\"filter-phase-3\">Phase 3<\/label>\n                                                <\/div>\n                                                <div class=\"form-item check-item\">\n                                                    <input type=\"checkbox\" id=\"filter-phase-4\">\n                                                    <label for=\"filter-phase-4\">Phase 4<\/label>\n                                                <\/div>\n                                            <\/div>\n                                        <\/fieldset>\n    \n                                                                                \n                                            \n                                                                                    <fieldset>\n                                                <legend>Filter by status:<\/legend>\n                                                <div class=\"filter-checkboxes\">\n                                                                                                                                                                                                                                                                                        <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-active-not-recruiting\" value=\"filter-rec-stat-active-not-recruiting\">\n                                                                <label for=\"filter-rec-stat-active-not-recruiting\">Active, Not Recruiting<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-recruiting\" value=\"filter-rec-stat-recruiting\">\n                                                                <label for=\"filter-rec-stat-recruiting\">Recruiting<\/label>\n                                                            <\/div>\n                                                                                                                                                                               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                                              <input type=\"checkbox\" id=\"filter-rec-stat-not-started\" value=\"filter-rec-stat-not-started\">\n                                                                <label for=\"filter-rec-stat-not-started\">Not started<\/label>\n                                                            <\/div>\n                                                                                                                                                                                                                                                                                                                                                <div class=\"form-item check-item\">\n                                                                <input type=\"checkbox\" id=\"filter-rec-stat-not-yet-recruiting\" value=\"filter-rec-stat-not-yet-recruiting\">\n                                                                <label for=\"filter-rec-stat-not-yet-recruiting\">Not yet recruiting<\/label>\n                                                            <\/div>\n                                                                                                                                                            <\/div>\n                                            <\/fieldset>\n                                            \n                                        <div class=\"filter-footer\">\n                                            <div class=\"filter-footer-reset\">\n                                                <a class=\"button button-text\" href=\"#\">Reset all filters<\/a>\n                                            <\/div>\n                                            <div class=\"filter-footer-submit\">\n                                                <a class=\"button button-text\" href=\"#\">Cancel<\/a>\n                                                <input type=\"submit\" class=\"button\" value=\"Apply filters\">\n                                            <\/div>\n                                        <\/div>\n                                    <\/form>\n                                <\/div>\n                            <\/div>\n                        <\/div>\n                    <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n\n    <!-- Research Pipeline block -->\n    <div class=\"block bg-band pipeline-listing-main\">\n        <div class=\"wrapper\">\n            <div class=\"inner-wrapper\">\n                                                                            \n                                        <div class=\"pipeline-listing pipeline-skeletal-conditions\">\n                        <h2 class=\"h3\">Skeletal Conditions<\/h2>\n\n                                                                                                                                        <h3 class=\"h5 trial-phase trial-phase\">Trial phase<\/h3>\n\n                            <div class=\"pipeline-group\" data-trial-phase-class=\"trial-phase\">\n                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                \n                                                                            <div class=\"pipeline-headers\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">Program (Trial)<\/div>\n                                                <div class=\"pipeline-condition\">Condition<\/div>\n                                                <div class=\"pipeline-technology\">Technology<\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                        <\/div>\n                                    \n                                    \n                                    <article class=\"pipeline-trial pre-ind phase-1 phase-2 phase-3 filter-condition-achondroplasia filter-tech-peptide filter-rec-stat-recruiting\">\n                                        <div class=\"pipeline-summary\">\n                                            <div class=\"pipeline-headers-summary\">\n                                                <div class=\"pipeline-product\">\n                                                    <h3 class=\"h5\">BMN 333 Long-Acting CNP<\/h3>\n                                                    <p>(333-301 [ASPEN])<\/p>\n                                                    <p class=\"status\"><span class=\"label\">Trial Status<\/span> <span class=\"status\">Recruiting<\/span><\/p>\n                                                <\/div>\n                                                                                                    <div class=\"pipeline-condition\">\n                                                        <h4 class=\"h5\">Condition<\/h4>\n                                                        <p>Achondroplasia<\/p>\n                                                    <\/div>\n                                                                                                                                                    <div class=\"pipeline-technology\">\n                                                        <h4 class=\"h5\">Technology<\/h4>\n                                                        <ul>\n                                                            <li>Peptide<\/li>\n                                                        <\/ul>\n                                                    <\/div>\n                                                                                                <div class=\"pipeline-details\">\n                                                                                                            <h4>Title<\/h4>\n                                                        <p>A Phase 2\/&#x200B;3 Study to Evaluate the Efficacy and Safety of BMN 333 Versus Vosoritide in Children With Achondroplasia (ASPEN)<\/p>\n                                                    \n                                                                                                            <h4>Study Description<\/h4>\n                                                        <p>To evaluate the effects of BMN 333 on growth compared with vosoritide in participants with achondroplasia who have not received any growth-promoting treatments. The study includes 2 parts: the Phase 2 part will select the optimal BMN 333 dose to be used in Phase 3 and determine study continuation into Phase 3; the Phase 3 part will compare the effects of the selected dose of BMN 333 with vosoritide.<\/p>\n                                                    \n                                                                                                            <div class=\"detail-boxes\">\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Primary Outcome Measure*<\/h4>\n<ul>\n<li>Predicted annualized growth velocity (AGV; Phase 2) and AGV (Phase 3)<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Inclusion Criteria*<\/h4>\n<ul>\n<li>Aged &ge; 2 to &lt; 11 years (Phase 2) or &ge; 2 to &lt; 18 years (Phase 3)<\/li>\n<li>Achondroplasia (confirmed by documented genetic testing) and open epiphyses<\/li>\n<li>Tanner Stage I (Phase 2) or any Tanner stage (Phase 3)<\/li>\n<li>Ambulatory and able to stand without assistance<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Secondary Outcome Measures*<\/h4>\n<ul>\n<li>Change from baseline in standing height, height Z-score, and upper to lower body segment ratio<\/li>\n<li>Incidence of adverse events (AEs), serious AEs, and events of interest<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                                                                                            <div class=\"box\">\n                                                                    <h4>Select Exclusion Criteria*<\/h4>\n<ul>\n<li>Any short stature condition other than achondroplasia<\/li>\n<li>History of any renal insufficiency or cardiac\/ cardiovascular disease that places the participant at increased risk of an adverse cardiac outcome in the setting of hypotension<\/li>\n<li>Bone fractures of the long bones or spine within 6 months prior to screening<\/li>\n<li>Used vosoritide, any other approved product (except growth hormone [GH], as detailed below), investigational product, or investigational medical device for the treatment of achondroplasia or short stature at any time<\/li>\n<li>Been treated with GH, insulin-like growth factor 1, or anabolic steroids in the 6 months prior to treatment start<\/li>\n<\/ul>\n                                                                <\/div>\n                                                                                                                    <\/div>\n                                                    \n                                                    <p>* Additional measures\/criteria may apply.<\/p>\n                                                                                                            <p><a class=\"button button-text button-external\" href=\"https:\/\/clinicaltrials.gov\/study\/NCT07441876\" target=\"_blank\">For reference and comprehensive trial information, visit ClinicalTrials.gov NCT07441876<\/a><\/p>\n                                                                                                    <\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases pipeline-inline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">Pre-IND<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">Phase 1<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">Phase 2<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">Phase 3<\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">Phase 4<\/div>\n                                                <div class=\"pipeline-expand\"><\/div>\n                                            <\/div>\n                                            <div class=\"pipeline-phases\">\n                                                <div class=\"pipeline-phase pipeline-phase-pre-ind\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-1\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-2\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-3\">\n                                                    <div class=\"phase-progress phase-progress-100\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-phase pipeline-phase-4\">\n                                                    <div class=\"phase-progress phase-progress-0\"><div class=\"phase-progress-inner\"><\/div><\/div>\n                                                <\/div>\n                                                <div class=\"pipeline-expand\">\n                                                    <div class=\"trigger\"><\/div>\n                                                <\/div>\n                                            <\/div>\n                                        <\/div>\n                                    <\/article>\n                                                            <\/div>\n                                            <\/div>\n                            <\/div>\n        <\/div>\n    <\/div>\n<\/div>\n\n<div id=\"acf-block-68ecfd62c135f\" class=\"block resources-listing\">\n\t<div class=\"wrapper\">\n\t\t<div class=\"inner-wrapper\">\n\n                            <div class=\"listing-title\">\n                                            <h2>Congress Posters and Presentations\n<\/h2>\n                                                                <p>All displayed posters and presentations are protected by copyright and are intended for individual use only.<\/p>\n<p><i><b>Please Note<\/b>: Poster content may be unavailable or delayed. This could be due to copyright or embargo guidelines.<\/i><\/p>\n<p>You may check back later or contact&#xA0;<a href=\"mailto:medinfo@bmrn.com\">medinfo@bmrn.com<\/a>&#xA0;or&#xA0;<a class=\"external_link\" href=\"https:\/\/www.biomarin.com\/web-request-form?_gl=1*1hs6n10*_ga*MTg0MDExMDAwMS4xNjg2MDQ0Nzc4*_ga_KGGE14VN95*MTY4NjEzNTY1Ni4xMC4xLjE2ODYxMzU3OTAuMC4wLjA.&amp;_ga=2.9066165.141314881.1686044782-1840110001.1686044778\" target=\"_blank\" rel=\"noopener\">complete a request form<\/a>&#xA0;to inquire about this specific material<\/p>\n                                    <\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":3,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-6899","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site 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